The introduction of proprotein convertase subtilisin/kexin type 9 (PCSK-9) inhibitors in 2015 was a promising addition to hypercholesterolemia therapies, but their cost and subcutaneous administration has limited their use, and therefore, new affordable and patient friendly treatment strategies are crucial to help reduce ASCVD risk.  |  Furthermore, bempedoic acid is a prodrug that becomes activated by an enzyme expressed primarily in the liver, allowing it to avoid the potential myotoxicity associated with statin therapy. Bempedoic acid, a drug currently under investigation, is a small molecule that has been shown to upregulate LDL receptors, decrease LDL-C, and reduce atherosclerotic plaque formation in hypercholesterolemic patients. Get the latest public health information from CDC: https://www.coronavirus.gov. Relevance to Patient Care and Clinical Practice: Statin therapy remains the mainstay of treatment for both primary and secondary prevention. 2020 May;80(7):747-753. doi: 10.1007/s40265-020-01308-w. 2017 Focused Update of the 2016 ACC Expert Consensus Decision Pathway on the Role of Non-Statin Therapies for LDL-Cholesterol Lowering in the Management of Atherosclerotic Cardiovascular Disease Risk: A Report of the American College of Cardiology Task Force on Expert Consensus Decision Pathways. Based on available data, bempedoic acid significantly lowers LDL-C and other atherogenic lipoprotein measures, and high-sensitivity C-reactive protein when added to background lipid-lowering therapy in patients with and without statin intolerance. Curr Opin Lipidol. Get the latest public health information from CDC: https://www.coronavirus.gov. Furthermore, bempedoic acid is a prodrug that becomes activated by an enzyme expressed primarily in the liver, allowing it to avoid the potential myotoxicity associated with statin therapy. Conclusions: The recent FDA approval of bempedoic acid offers an additional option for lowering LDL-C levels in patients with atherosclerotic cardiovascular disease or heterozygous familial hyperlipidemia. USA.gov. This site needs JavaScript to work properly. Barkas F, Milionis H, Kostapanos MS, Mikhailidis DP, Elisaf M, Liberopoulos E. Curr Med Res Opin. 2015 Feb;31(2):221-8. doi: 10.1185/03007995.2014.982751. Bempedoic acid is a prodrug and requires activation by the enzyme very-long-chain acyl-CoA synthetase 1, which is present in the liver but absent in most peripheral tissues. Epub 2018 Jun 12. Eligibility for PCSK9 Inhibitors According to American College of Cardiology (ACC) and European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) Guidelines After Acute Coronary Syndromes. Wang X, Zhang Y, Tan H, Wang P, Zha X, Chong W, Zhou L, Fang F. Cardiovasc Diabetol. Lloyd-Jones DM, Morris PB, Ballantyne CM, Birtcher KK, Daly DD Jr, DePalma SM, Minissian MB, Orringer CE, Smith SC Jr. J Am Coll Cardiol. Banach M, Duell PB, Gotto AM Jr, Laufs U, Leiter LA, Mancini GBJ, Ray KK, Flaim J, Ye Z, Catapano AL. Data Sources: A PubMed search was conducted from January 2000 to June 15, 2020, using the keyword bempedoic acid for phase III clinical trials published in the English language. NLM However, many patients cannot tolerate statin therapy because of statin-associated muscle symptoms. 2020 Aug 24;9:2020-6-5. doi: 10.7573/dic.2020-6-5. Bempedoic acid (BA; ETC-1002) is a new agent that reduces cholesterol synthesis through inhibition of adenosine triphosphate citrate lyase, an enzyme upstream from 3-hydroxy-3-methylglutaryl-coenzyme A.In animal models, BA also influences fatty acid synthesis, but in humans, its role is limited primarily to lowering low-density lipoprotein cholesterol (LDL-C). Gencer B, Koskinas KC, Räber L, Karagiannis A, Nanchen D, Auer R, Carballo D, Carballo S, Klingenberg R, Heg D, Matter CM, Lüscher TF, Rodondi N, Mach F, Windecker S. J Am Heart Assoc. Efficacy and safety of bempedoic acid added to ezetimibe in statin-intolerant patients with hypercholesterolemia: A randomized, placebo-controlled study. JAMA Cardiol. Get the latest research from NIH: https://www.nih.gov/coronavirus.  |  2020 Jul 1;5(10):1-12. doi: 10.1001/jamacardio.2020.2314. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Drugs. Bempedoic acid is administered orally once a day, is quickly absorbed in the small intestine, and has a half-life ranging from 15 to 24 hours . Drugs Context. Clipboard, Search History, and several other advanced features are temporarily unavailable. In this review, we report the lipid-lowering effects associated with bempedoic acid, and the safety profile from multiple clinical trials.  |  2020 Aug 12;19(1):128. doi: 10.1186/s12933-020-01101-9. Data Synthesis: The findings from this review show that bempedoic acid is a safe and effective option for lowering LDL-C levels in patients requiring LDL-C lowering for primary or secondary prevention of cardiovascular events. 2017 Apr;23(Suppl 2):1-87. doi: 10.4158/EP171764.APPGL. 2017 Oct 3;70(14):1785-1822. doi: 10.1016/j.jacc.2017.07.745. HHS 2019 Feb;30(1):1-9. doi: 10.1097/MOL.0000000000000565. Atherosclerosis. Introduction: Bempedoic acid (ETC-1002) is a first-in-class lipid-lowering agent recently approved by the United States (US) Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for commercialization. Bempedoic acid may be a reasonable adjunct for LDL-C reduction, though further evaluation of cardiovascular outcomes with bempedoic acid in this population is needed. Abstract. Please enable it to take advantage of the complete set of features! 2018 Oct;277:195-203. doi: 10.1016/j.atherosclerosis.2018.06.002. Bempedoic acid for the treatment of dyslipidemia. Lessons from a lipid clinic. Keywords: Bempedoic Acid (Oral) Reviews Be the first to review Bempedoic Acid (Oral) and share your experience with other Everyday Health users. J Cardiovasc Pharmacol. Online ahead of print.  |   |  Additional data regarding effect on long-term cardiovascular outcomes with bempedoic acid are currently being studied. How effective are the ESC/EAS and 2013 ACC/AHA guidelines in treating dyslipidemia? COVID-19 is an emerging, rapidly evolving situation. By inhibiting ACLY, bempedoic acid induces LDL receptor upregulation and stimulates the uptake of LDL particles by the liver, which contributes to reduction of LDL-C concentration in the blood . Despite the widespread use of statins and ezetimibe to decrease low-density lipoprotein cholesterol (LDL-C) levels and associated atherosclerotic cardiovascular disease (ASCVD), many patients do not achieve adequate LDL-C lowering as per the recommended American College of Cardiology (ACC)/American Heart Association (AHA) and European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) guidelines and demonstrate residual cardiovascular risk. NLM Objective: To review the pharmacology, pharmacokinetics, safety, and efficacy of bempedoic acid for low-density lipoprotein cholesterol (LDL-C) reduction. Association of Bempedoic Acid Administration With Atherogenic Lipid Levels in Phase 3 Randomized Clinical Trials of Patients With Hypercholesterolemia.

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